Nefropatía por iga (enfermedad berger)

Abstract

Immunoglobulin A nephropathy (IgAN) is the most common glomerular pathology, with a higher incidence in men, excess IgA accumulates in the kidneys, particularly IgA1Galactosyl-deficient (IgA1-Gd), causing local inflammation that progressively in Time directly affects the renal filtration capacity, accumulating toxins in the blood, therefore the objective of this study is to define the immune response and cellular elements involved in patients with nephropathy, through a bibliographic review, to understand the process at the cellular level. , since IgA is the type of immunoglobulin with the greatest circulation in the body, the initial event is the deposit in the IgA mesangium, predominantly polymeric IgA of subclass IgA 1, with co-deposits of IgG and C3, and less frequent of C1q, The latter, when present, can be related to a poor prognosis of the disease. IgAN is associated with different factors, it can even be the product of complications from other conditions such as Kabuki syndrome or selective IgA deficiency, which are related to multiple factors. digestive and respiratory tract infections and increased intestinal permeability. In IgA nephropathy, the complement, whose immune role is essential, is supported by the presence of deposition of complement components in the glomeruli, in most patients the IgA1 subclass is present and not IgA2, in most cases the patients they present symptoms when the disease has progressed and present renal failure.