Formulación de ampicilina en polvo para administrar como suspensión extemporánea

Abstract

A bibliographical investigation was carried out, where it was verified that ampicillin is not very stable, insoluble, and unstable in water, due to various factors, the main one being the breakage of the β-lactam ring, due to the hydrolysis that is generated. That is why it is decided to present a proposal to elaborate an extemporaneous suspension so that the active principle does not present instabilities and thus achieve the required therapeutic action. For this, the appropriate excipients must also be selected to formulate correctly. Therefore, an elaboration procedure was proposed with the use of a micro-pulverizer with a #20 mesh sieve, which guarantees obtaining a mixture and an adequate homogeneous particle size without lumps in such a way that it preserves its quality and stability. As a final point, a stability study is proposed to evaluate the aptitude to conserve its properties under official quality specifications in an established period of time to determine the useful life.