Calidad biofarmacéutica de comprimidos genéricos de ibuprofeno en comparación con el medicamento innovado

Abstract

Ibuprofen is an NSAID or non-steroidal anti-inflammatory drug that has analgesic, anti-inflammatory and antipyretic effects, which are beneficial since they help combat acute and chronic pain in various tissues of the body. Various administrations, both generic and brand name, are sold and tested, which are subjected to various tests to see if they are safe and effective when administered. The objective of the study was to analyze different scientific articles analyzing the biopharmaceutical quality of ibuprofen. Thus, allowing to evaluate parameters such as weight uniformity, hardness, friability, dissolution and bioavailability studies; these were given in vitro by means of dissolution profiles and in vivo by analyzing factors such as maximum time, elimination constant, maximum concentration and area under the reference curve. Finally, the results obtained, manage to determine that most of the revised ibuprofen presentations do comply with the biopharmaceutical quality parameters, therefore, it is concluded that they are therapeutic equivalents.