La inflamación como respuesta inmunológica de la EPOC

Abstract

Chronic obstructive pulmonary disease (COPD) is a respiratory disease characterized by chronic and progressive airflow restriction and is not completely reversible. The main symptoms are dyspnea and cough, accompanied by expectoration, due to the inflammatory response of the body when in contact with harmful particles such as those produced by tobacco. Objective: To interpret the alteration of the immune response that the organism acquires, against the harmful substances that it contains in tobacco by reviewing scientific articles for a better understanding of COPD. Methodology: analytical, descriptive method, based on the bibliographic review of scientific articles, indexed in scopus, science direct, scielo, allowing to evaluate the response developed against the pathology. Result: Cigar smoke is an innate response activator that causes pathological changes that lead to narrowing of the small airways and destruction of the lung parenchyma, also known as emphysema. Classically, these changes were associated with macrophages and neutrophils, NK cells, dendritic cells, although later CD8 + T and CD4 + T lymphocytes were added.