Identificación y cuantificación del ketorolaco como posible principio activo de un medicamento de identidad dudosa.

Abstract

The pharmaceutical biochemist must be a professional with the ability to apply a variety of methods and techniques to determine and quantify drugs, whose origin may be unknown. Many times, due to human reasons or external factors, the medicines that are stored can deteriorate, especially their labels, preventing us from knowing which medicine it is. To correct this situation, instrumental methods are used to identify and quantify the possible active ingredient. This would be the problem of the present investigative work that would have as a general objective, to determine, from a qualitative and quantitative point of view, ketorolac as a possible drug of a medicine, through the corresponding instrumental methods established in the official monographs, with the purpose of giving it validity to a lot showing visible packaging deterioration. The present work is of a non-experimental nature, it is a descriptive study based on the compilation of information from bibliographic sources, related to the instrumental methods of identification and quantification of the doubtful drug. As a result, the usefulness of the high resolution liquid chromatography (HPLC) method is described, as well as the analysis through visible ultraviolet spectroscopy, to determine the identity of the drug, according to official regulations.