Análisis de métodos analíticos para la determinación del acetaminofén (paracetamol) en un medicamento

Abstract

Acetaminophen or paracetamol is one of the most widely used drugs worldwide in the field of health to relieve acute pain and minimize fever, belonging to the group of antipyretics and analgesics, for this reason pharmaceutical industries and quality laboratories use analytical methods with which to obtain precise, accurate and reliable results. For the development of this research, the general objective was to analyze the analytical methods for the determination of purity and concentration of acetaminophen (Paracetamol) in a medicine, guaranteeing its quality and therapeutic efficacy, applying a descriptive methodology since a bibliographic review of high impact scientific articles, reports, theses, academic journals and books was performed, however, it is considered of experimental nature because analyses are performed in laboratories to determine the analytical methods used, These are high performance liquid chromatography HPLC, ultraviolet-visible spectroscopy, mass spectrometry, infrared spectroscopy and capillary electrophoresis, in addition, the HPLC method was compared with the Ultraviolet-visible spectroscopy method (UV-Vis), reaching the conclusion that the HPLC method is the most used by the authors occupying 38.48% due to its high sensitivity, accurate, efficient and reliable results, characteristics that allow ensuring the quality and effectiveness of the therapies.