Autohemoterapia como coadyuvante al tratamiento con vincristina en perros, diferentes tipos de tumor venénero transmisible atendidos en la clínica utmach

Abstract

Transmissible Venereal Tumor (TVT) is a neoplasm that occurs in dogs, especially in those without adequate reproductive control, and is transmitted mainly by contact during courtship, by licking the affected area and by appearance. This study evaluated the effectiveness of autohemotherapy as an adjuvant to treatment with vincristine sulfate in dogs diagnosed with different types of TVT at the UTMACH teaching clinic. A total of 13 dogs (n=13) were included in the diagnostic part (Cytology) and 9 dogs (n=9) in the chemotherapy part.The cytopathological classification of TVT revealed that 23.1% corresponded to the lymphocytoid type, 69.2% to the plasmacytoid type, and 7.7% to the mixed type. The parentage of the dogs showed that 15.4% were purebred and 84.6% mixed breeds. In terms of sex, 53.8% were females and 46.2% were males. No significant association was found between the type of TVT and factors such as filiaxion, sex, age, reproductive status, body condition or location of the neoplasm. Most cases were diagnosed in adult and whole dogs, and the location of the neoplasm varied between males and females without statistically significant patterns. The results indicated that treatment with autohemotherapy improved the clinical response of dogs with TVT, gradually reducing tumor size and decreasing side effects compared to treatment with vincristine sulfate since treatment 2 (T2 = Autohemotherapy + Vincristine sulfate) resulted in a partial response in all cases during the four weeks, while treatment 1 (T1 = Vincristine sulfate) presented mixed responses. Although there were no significant differences in efficiency, treatment 2 (T2) showed a gradual reduction of the tumor, especially in males, suggesting a possible benefit in conventional treatment.