Proceso de elaboración de una forma farmacéutica líquida con actividad antileishmanial a partir del aceite esencial de chenopodium ambrosioides (paico)

Abstract

Leishmaniasis is a disease caused by the <i>leishmania</i> parasite transmitted by the bite of female sandflies. For the treatment of this disease, studies have been carried out with the essential oil (EO) of <i>Chenopodium ambrosioides</i> against this parasite with positive results. Emulsions for oral use are pharmaceutical preparations made from two immiscible liquids, generally water and oil. The formulation of an O/W emulsion is a viable option for integrating <i>C. ambrosioides</i> EO as the active ingredient. The elaboration of this product requires unitary operations and equipment, as well as specific quality parameters, in compliance with good manufacturing practices. This research describes the procedures to elaborate a liquid pharmaceutical form for oral use (emulsion) from the EO of <i>C. ambrosioides</i>, specifying the components for the formulation, unitary operations, equipment and the different quality controls that must be applied in the development and finished product to guarantee the quality and effectiveness of it.