Alteraciones genéticas en perros de raza collie que provocan una reacción frente a la ivermectina.

Abstract

Currently, intoxications are one of the most frequent cases present in the different veterinary centers, some by accident and others by the presence of genetic mutations, so we must be very careful with all drugs, especially with those that are carried by the P-glycoprotein and its substrates, unless we are aware that they are not carriers of the MDR1 gene mutation or another gene, since breeds such as the Collie have adverse reactions to the administration of ivermectin. Ivermectin is administered in patients older than 4 months of age, and its toxicity is especially related to the P-glycoprotein system. In those susceptible breeds due to mutation of the MDR1 gene, symptoms and signs such as tremors, mydriasis, blindness, coma, etc. are evidenced; this is due to the non-functionality of the P-glycoprotein, causing them to cross the blood-brain barrier and directly affect the CNS. Treatment for ivermectin poisoning includes emesis, intravenous therapy, administration of physostigmine or activated charcoal. Genetic mutation is a finding that requires continuous study as new data are obtained each time leading to new individuals affected by intoxications with products such as ivermectin.