Análisis de anticuerpos en el diagnóstico de lupus eritematoso sistémico

Abstract

Introduction: Systemic Lupus Erythematosus is an autoimmune, chronic, multisystemic entity, whose main immunopathological characteristic is the union of autoantibodies and immunocomplexes in organs and tissues, affecting more the female than the male sex; It is known that for a correct diagnosis, antinuclear antibodies are the key serological marker for patients with Lupus. Objective: To determine which serological markers help the correct diagnosis of Systemic Lupus Erythematosus. Development: A literature review was made in the Pub-Med and Science Direct database. Conclusion: Antinuclear antibodies in general and especially anti-dsDNA and Anti-Sm are considered essential serological markers for the diagnosis of SLE since they have shown high sensitivity and specificity in comparison to other markers. Currently Anti-Nuc and Anti-C1q according to studies will be promising antibodies for the diagnosis of SLE.