Espectroscopia ultravioleta visible en el campo farmacéutico. estimación de maleato de asenapina en materia prima y formas farmacéuticas

Abstract

UV-visible spectroscopy is generally used for the identification and quantification of components of solutions of transition metal ions and highly conjugated organic compounds. The pharmacopeias and updated scientific literature describe a large number of active ingredients that are evaluated and quantified by applying this technique. The practical problem posed requires the selection of a scientific work that applies this spectroscopic method within the pharmaceutical industry, so the objective of the work is to describe an analytical method that uses UV-visible spectroscopy, based on the analysis of updated scientific literature, for the demonstration of its application in the pharmaceutical industry. It describes in detail the detection and quantification of the drug, using UV-Visible spectroscopy. Additionally, the validation parameters are determined: linearity, precision, robustness, accuracy, limit of detection and quantification, to demonstrate the validity of the method. At the end of the work, the application of UV-Visible spectroscopy in the pharmaceutical industry was finished, through examples. The experimental conditions used, the structural characteristics of the active principle and the selected validation parameters of a UV-Visible spectroscopy method for the determination of asenapine in raw materials and pharmaceutical formulations were also analyzed.