Determinar las causas predisponentes y desencadenantes, así como su control del síndrome de cushing iatrogénico en caninos.

Abstract

Hyperadrenocorticism is an endocrine disease affecting more adult canines, considering the levels of cortisol by means of radioimmunoassay tests the values of 20-250 nmol/l (0.7-9 µg/dl) and control values 2.1 (0.8 - 4.5µg / dl). Having a prevalence of 48% in the US, 27.4 in Chile, 0.28% in the UK. Referring to the fact that the adrenal glands are found in the cranial-medial part of the kidneys the same as the glomerular, fascicular, and reticulated areas are found in the cerebral cortex. Presenting as adrenal hyperadrenocorticism in a slow way and increases in the daily secretion of cortisol; Another cause is hyperadrenocorticism by receptors in the adrenal cortex, resulting in an increase in ACTH production, causing bilateral adrenocortical hyperplasia, which can affect its diagnosis and the other cause in iatrogenic hyperadrenocorticism, the same that is produced. by the constant consumption of glucocorticoids. Among the most common signs are polyphagia, polyuria, polydipsia, muscle weakness, dermatological signs such as alopecia, comedones. For the diagnosis, the present signs must be analyzed, laboratory tests, ultrasound, elimination tests with dexamethasone in high and low doses should be carried out, and in this way to be able to reach a treatment either surgical or pharmacological such as the use of Trilosano in doses of 0.7mg/kg/day; Mitotane at 25 - 50 mg/kg/day; Ketoconazole 5mg / kg twice a day. Being this disease detrimental to the health of the canines so it has to be treated in time to administer the appropriate treatment.