Estudio comparativo de la calidad biofarmacéutica de medicamentos antiinflamatorios no esteroides genéricos con el innovador

Abstract

Non-steroidal antiinflammatory drugs (NSAIDs) are drugs with antipyretic, analgesic and antiinflammatory activity, which help fight acute and chronic pain in various tissues of the body. On the market there are a wide variety of anti-inflammatory drugs in solid pharmaceutical presentations in generic or brand name, which are subjected to tests to determine if they are safe and effective at the time of being administered. The objective of this work is a bibliographic review of various anti-inflammatory to know if they comply with biopharmaceutical quality, where parameters of weight uniformity, hardness, friability, disintegration time and active ingredient assessment in addition bioavailability studies in an uncompromising way, in vitro through dissolution profiles, and in vivo by analyzing the area under the curve, maximum time, maximum concentration, between, the reference drug and the test drug, whose values are compared to determine their therapeutic equivalence.