Fundamentos en el manejo terapéutico actual de los gastrinomas esporádicos y asociados a men 1

Abstract

Introduction: Gastrinoma is a rare neuroendocrine neoplasm characterized by excessive production of gastrin that causes hypersecretion of gastric acid, leading to Zollinger-Ellison syndrome. Its incidence is 0.5 to 4 cases per million individuals per year, with a higher prevalence in men. For its diagnosis, the measurement of serum gastrin is used as an initial test and different imaging means are used to locate it. Treatment is multidisciplinary, based on symptom control with proton pump inhibitors and surgery with curative intent, the practice of which is controversial in patients with MEN-1. Objective: To summarize the current therapeutic management of sporadic gastrinoma associated with MEN-1, through a bibliographic review that allows providing an updated document that serves as a source of consultation for care and teaching in medical students and general practitioners. Methodology: The present study is descriptive in nature based on a bibliographic search of updated literature from the last 5 years in high-impact indexed journals in databases such as PubMed, LILACS, Google Scholar. Conclusion: Gastrinoma is a rare nosological entity and its diagnosis and consequent management is a challenge. It’s essential to make a differential diagnosis with other diseases producing hypergastrinemia; it’s also important to rule out MEN-1, because its therapeutic management differs from sporadic gastrinoma, mainly in the indication of surgical intervention, being ultimately the pillars of treatment symptom relief and surgery.