La clave patogenica de s. aureus en las enfermedades infecciosas

Abstract

This work focuses on the molecular mechanisms underlying the synthesis and function of the extracellular polysaccharide in Staphylococcus aureus. Some strains exhibit the ability to produce an extracellular polysaccharide that plays a significant role in their pathogenicity and virulence. This polysaccharide structure acts as a protective capsule that inhibits phagocytosis, thus preventing internalization and degradation of the bacteria by phagocytes of the immune system. In addition, the capsule favors the adherence of S. aureus to host cells and biomedical surfaces, which facilitates its colonization and persistence in the host. Its ability to invade and colonize different tissues and organs is a determining factor in the severity of infections caused by this pathogen. For this reason, it is important to consider the objective of describing the virulence factors and mechanisms of action of Staphylococcus aureus, using a bibliographic review, in order to have a better understanding of the bacterium. In the investigation, mechanisms of action were determined, such as the production of extracellular polysaccharides and the capsule, which has been shown to be a factor that inhibits phagocytosis by making it difficult for phagocytes to recognize and adhere to S. aureus. This ability allows it to persist and spread in the host, leading to potentially serious infections with significant clinical consequences. In conclusion, it is important to take into account that knowing these mechanisms of action and the virulence of a bacterium allow better control of bacterial infections.