Diagnóstico hematológico de la enfermedad púrpura trombocitopénica trombótica.

Abstract

In the resolution of the clinical case, the hematologic profile presented by the patient and how it relates to the final diagnosis will be analyzed. The clinical case is about a female patient 59 years old, with a medical history of psoriasis, vitiligo and psoriatic arthritis, family history of mother with liver cirrhosis. She comes to medical attention for clinical picture of 9 days of evolution with holocranial headache, pain in upper hemiabdomen, general malaise, asthenia, pain in lumbar region, anorexia, hematuria and episode of melena, resulting in Thrombotic Thrombocytopenic Purpura, in the laboratory results the presence of platelets, schistocytes >5% in the peripheral blood smear test, increased LDH and indirect bilirubin, reduced haptoglobin. This is Microangiopathic Hemolytic Anemia (MHAA), like thrombocytopenia, it is a disease that is triggered by Thrombotic Thrombocytopenic Purpura (TTP), taking into account when relating secondary disease in this case Hemolytic Uremic Syndrome (HUS) ruling out viral infections negative and complement resulting in normal range. PTT disease is complicated at the time of diagnosis due to the high cost of tests such as Shiga Toxin and ADAMTS13 activation.