Determinación de la pureza y concentración del acetaminofén para garantizar su actividad farmacológica

Abstract

Medicines are essential for the protection, prevention and treatment of diseases, strict control of purity and concentration is necessary. Paracetamol is considered a safe drug due to its wide therapeutic range, poisoning is relatively common among the population. Legal requirements must be met in medicines: effectiveness, safety, quality and marketed with precise identification and relevant information. The objective of the research is to identify the analytical methods through bibliographic sources for the determination of the purity and concentration of acetaminophen (Paracetamol), to guarantee its pharmacological activity, the methodology used was descriptive-investigative, where it was possible to collect information from multiple databases, scientific articles, theses and books, in order to address information within the period 2018 - 2022 where it was possible to know the methods used for an adequate control of purity and concentration. Finally, the pharmacological activity of acetaminophen was evaluated, as well as adverse drug reactions that can manifest as skin rashes due to overdose, to reduce possible risks in the population. On the other hand, the most used analytical methods for the detection of purity and concentration were identified, among which are high resolution chromatography (HPLC) with 65%, and Ultraviolet-Visible Spectroscopy with 35% utility.