Influencia de las interacciones farmacocinéticas entre fármacos utilizados como alternativas terapéuticas para Covid-19

Abstract

During the pandemic, alternatives for an effective treatment against SARS-CoV-2 infection have been investigated. The drugs that have been used to treat the disease are: antivirals, antibiotics, antimalarials, immunosuppressants, immunomodulators, and corticosteroids, which have been used irrationally, without taking into account pharmacokinetic interactions, which can affect absorption, metabolism, and elimination. (ADME). This research aims to analyze the influence of pharmacokinetic interactions between drugs used as therapeutic alternatives for COVID-19, through a bibliographic review to understand their importance in clinical practice. The descriptive method was applied to search for relevant and current information on the main drugs used and the pharmacokinetic interactions that occur. The results obtained show that the administration of different groups of drugs without knowing their pharmacokinetic interactions causes alterations in different pharmacokinetic indicators, affecting the effectiveness of the treatment. It is concluded that pharmacokinetic studies in clinical and therapeutic practice are relevant for understanding the pharmacokinetics of drug molecules and the influence of their activity on each other, as well as plasma concentrations if they are within the therapeutic range in this way. may exert the desired pharmacological effect, or if applicable, if they have caused adverse reactions in the patient, which may be produced by pharmacokinetic interactions that affect the ADME process, and thus arrive at an individualized pharmacotherapy for therapeutic efficacy and improvement of the quality of life of the patient.