Fundamentos de la conducta terapéutica actual en pacientes con tumores estromales gastrointestinales

Abstract

Introduction: Gastrointestinal stromal tumors are mesenchymal neoplasms originating from mutations of the tyrosine kinase receptors of the interstitial cells of Cajal, whose worldwide incidence is approximately 15 cases per million inhabitants, these tumors have an uncertain behavior, but they tend to become malignant, so proper management is required to prevent their spread. Objective: To inform the management of gastrointestinal stromal tumors according to the most recent advances in medicine through the bibliographic review of scientific articles in repositories and indexed digital libraries that serve as a reference tool for medical students and residents. Materials and methods: It is a bibliographic review of scientific articles published in the SCIELO, PUBMED, LILACS databases, in the last 5 years, and in regional journals for the search of local information. Conclusion: The continuous advances in medical research have shown the usefulness of surgical resection of local gastrointestinal tumors and the surveillance of these patients, while in metastatic tumors, treatment is based on the use of the four lines of inhibitors of approved tyrosine kinase, the use of chemotherapy and radiotherapy is not considered because they are ineffective in these cases, and new inhibitors and clinical trials are currently under development to implement immunotherapy as a line of treatment.