Mecanismo de acción de los plaguicidas organofosforados para producir la alteración de las colinesterasas frente a una intoxicación aguda

Abstract

Organophosphate pesticides are substances used very frequently in the agricultural sectors, which use them to eliminate all types of pests that interfere with the normal production of their products, these pesticides are considered harmful to human health due to their composition of nerve gases and for what it produces in the organisms such as affecting the normal activities of the cholinesterase enzymes which react causing stimulation on muscarinic and nicotinic receptors. The objective of this research work is to identify the mechanism of action of organophosphate pesticides in acute poisoning in people with exposure, through a bibliographic review in scientific publications, for the determination and diagnosis of acute poisoning. Based on the research carried out, the mechanism of action with which organophosphate pesticides, which by generating an inhibition of cholinesterase enzymes, produce acute intoxication in the body and generate damage to the central nervous system, was identified.