Análisis de interacciones y reacciones adversas en pacientes medicados con antiinflamatorios no esteroideos (aines) y tratamiento concomitante de enfermedades crónicas

Abstract

NSAIDs are the group of drugs most used and prescribed by doctors, they have anti-inflammatory, antipyretic, analgesic and antiplatelet pharmacological action. However, it has been shown that concomitant administration with other drugs can alter their pharmacokinetics and pharmacodynamics, untying drug interactions and ADRs. In this investigation, two clinical cases were addressed in which NSAIDs are involved: celecoxib and ASA in concomitant administration of treatment for chronic diseases. For the development, the general objective was to analyze the possible interactions and adverse reactions in patients medicated with non-steroidal anti-inflammatory drugs through a bibliographic review of scientific articles for the proposal of possible interventions that improve the quality of life of the treatments. To meet the objective, an exhaustive search of articles and scientific journals, web pages was carried out. According to what was investigated, it was concluded that the patients presented drug interactions in both cases at the pharmacokinetic level, which originated type A adverse reactions. In addition, interventions were proposed in the pharmacological treatment such as not continuing with the administration of the antiplatelet agent (clopidogrel). continue with the continuous administration of celecoxib 200 mg/24 h in case 1, while in case 2 it is recommended to change the anticonvulsant (AVP) for levetiracetam with an initial dose of 250 mg/12 h to a therapeutic dose of 500 mg/12 h for present fewer side effects or use it as coadjuvant therapy together with AVP, in addition to adding a PPI as gastroprotective for the administration of ASA as platelet antiaggregant.