Reconocimiento antigénico mediado por correceptores de linfocitos t y b: rechazo del trasplante.

Abstract

Transplantation has not only become an alternative for the treatment of diseases, but it is also a revolutionary clinical procedure capable of changing the quality of life of patients in terminal stages. The main cause that can trigger its rejection is the activation of the immune response mediated by its cells. Objective: To identify antigenic recognition mediated by T and B lymphocyte receptors in transplant rejection, through a review of scientific articles to understand the importance of the major histocompatibility complex in the immune response. Methodology: The methodology used in the resolution of this research is descriptive, for which the review of books and scientific articles published in scientific journals such as Scielo, Elsevier, EBSCO was carried out; guided to the development of the research topic. Result: For the recognition between the lymphocyte and the antigen to occur, the participation of correctors is necessary, which help the antigen molecule presented in the major histocompatibility complex to be identified by the lymphocyte. The CD4 and CD8 T lymphocyte co-receptors, in collaboration with the antigen-presenting cells, help transform the antigen peptide into a peptide-molecule, ready to be transported to the cell membrane where it will join the major histocompatibility complex. B lymphocyte co-receptors CD79 a and b, CD19 activate BCRs, initiating signal transduction, and co-receptors CD21, CD81 that help identification.