Enfoque diagnóstico y terapéutico de la cirrosis hepática de etiología no alcohólica.

Abstract

The main cause of Liver Cirrhosis in our environment is non-alcoholic Hepatic Steatosis, surpassing alcohol and viral etiologies, which is related to the increase in pathologies such as obesity and metabolic syndrome. The most affected age group ranges from 36 to 64 years. It is crucial to differentiate between Non-Alcoholic Fatty Liver, where the initial phase is the deposition of lipids in hepatocytes, and NASH, which is characterized by a change with inflammation that leads to fibrosis and, in turn, to Cirrhosis. Factors such as physical inactivity, an unbalanced and hypercaloric diet, aging, etc. lead to the pathogenesis of this disease. Therefore, first-line treatment should focus on the prevention of modifiable health factors in primary care, to avoid reaching clinical circumstances that require pharmacological treatment. Objective: To describe the management of liver cirrhosis through a systematic review of updated scientific articles to achieve a timely approach. Method: The following research work was carried out by collecting information in articles indexed in scientific platforms such as: PubMed, Scielo, Google Scholar, Cochrane, among others, where 20 articles have been chosen in the range of the last 5 years considering the more scientifically relevant. Conclusions: The therapeutic approach is based on the restoration of metabolic changes intervening in lifestyle and pharmacological treatment should be able to improve steatosis, inflammation, degeneration and fibrosis.