Influencia de la cantidad de nutrientes en la vialidad celular de células con trastornos asociados al daño del ADN

Abstract

Cellular nutrition is of utmost importance since it allows our organism to fulfill the functionalities that biologically correspond to it, as long as it is provided in adequate proportions and conditions. Part of this importance lies in its usefulness to obtain the nutrients and resources necessary for the process of cell division, with which new tissues and consequently the corresponding organs are maintained or formed. Cell division proceeds normally as long as there is no damage to the genome of the cell; if, on the contrary, there are anomalies in the genetic structure, the cell stops the process until the damage is corrected. This occurs due to the action of control points that are in charge of regulating the cell division process, to guarantee that the new cell obtained is in ideal conditions. The aim of the present investigation was to determine the influence of nutrients on DNA quality. The clinical question was: What can preserve cell viability in disorders associated with DNA damage and genome instability? An exhaustive research was carried out in high impact journals, obtaining articles from Scielo, Redalyc and Scopus, which concluded that nutrients in high amounts, drag the cell to grow and divide; even with damage to the genetic structure of the cell.