Estudio de la calidad biofarmacéutica de los medicamentos prescritos en pacientes polimedicados

Abstract

Polypharmacy patients are patients whose pharmacological treatment uses more than five drugs. Most of the people who are polymedicated are elderly, which implies that there is no good pharmacological treatment, increasing the risk of mortality and morbidity. The following work aims to know if the drugs used in polymedicated patients comply with the biopharmaceutical quality parameters, which will guarantee that the drug is effective and safe for the patient through bibliographic research since in the market Currently there are drugs that do not meet these parameters and can cause complications in the health of patients. The articles analyzed have carried out various tests, including dissolution, disintegration, friability, hardness, maximum concentration and maximum time, all of which are parameters that are necessary for biopharmaceutical quality. Another of the parameters studied is the bioequivalence that a multi-source drug has compared to an innovator, this is done through in vivo and in vitro tests, which are the dissolution profile and bioavailability test to make comparisons between the drugs under study. important to know if the study drugs are interchangeable with each other. The studies analyzed in the bibliographic research work obtained satisfactory results since most of them meet the necessary parameters of biopharmaceutical quality