Estudio comparativo de la calidad biofarmacéutica de los medicamentos psicotrópicos multifuente con el innovador

Abstract

Psychotropic medications are those that contain active principles that act on psychological function and alter the mental state, such as antidepressants, hallucinogens and tranquilizers. There are a wide variety of psychotropic medications that can be used according to different psychic and neurological disorders, among which we have multi-source medications that are born as a viable alternative of lower cost in relation to innovative medications. The present work aims to demonstrate through a bibliographic review that the different psychotropic drugs marketed in the pharmaceutical market comply with those of biopharmaceutical quality. Among the quality tests applied to solid pharmaceutical forms are the uniformity of content, hardness, friability and disintegration time, which are important aspects for the approval of its commercialization. The analysis of the bioequivalence parameters sent in the different studies, allows to know if the multi-source and innovative drugs are interchangeable with each other, this through in vitro tests such as the dissolution profile and in vivo tests such as the bioavailability in magnitude and speed, whose results They are subjected to a comparison to determine that there are no significant differences, thus allowing to guarantee their efficiency and effectiveness. The results obtained in the studies analyzed in the present bibliographic review work have complied with the different parameters of biopharmaceutical quality and bioequivalence, reaching the conclusion that these are pharmaceutical and therapeutic equivalents. The results obtained in the studies analyzed in this literature review have complied with the different parameters of biopharmaceutical quality and bioequivalence, so it can be concluded that these are therapeutic equivalents.