Validación de técnica electroanalítica para determinación de diclofenaco en medios acuosos

Abstract

Diclofenac has become a very popular medication for patients due to its anti-inflammatory pharmacological action, which decreases the effect of prostaglandins, which cause inflammation and pain. Due to its inadequate final disposal, it causes ecological problems throughout the world, specifically in the fauna. Being part of the group of emerging pollutants, which are not regulated, despite the toxic effect capable of altering the biosphere, for example, the extinction of Asian vultures, 100% mortality of zebrafish embryos in concentrations (100mg / L) with 70% similarity to the human genome. The research described by the scientists detailed the presence of emerging contaminants, which indicate that once detected, their elimination is essential through various methods, such as physicochemical, biological and hybrid treatments to assess their persistence, through bioaccumulation that increase their concentration with the time in the environment for its mobility and transformation of toxic substances. Some studies verify the toxicity of diclofenac in aquatic biota, such as water flea species (Daphnia magna), at concentrations below 1 mg / l, due to oxidative stress that alters the activity of antioxidant enzymes. Studies on the acute and chronic toxicity of diclofenac in fern spores with the help of biomarkers point to a progressive deficit of mitochondrial activity.