Biomarcadores en artritis reumatoidea: importancia y valor diagnóstico en la práctica clínica

Abstract

Introduction: rheumatoid arthritis (RA) is a chronic inflammatory symmetric, destructive and sometimes multisystemic polyarthritis caused by the formation of pannus (inflammatory synovial tissue) thus invading the cartilage and bone, which without immediate treatment facilitates bone destruction by driving in this way to irreversible disability. Objective: To determine the importance of biomarkers and their usefulness in the diagnosis of rheumatoid arthritis. Methods: a bibliographical review was made in the PubMed, ScienceDirect and Google Academic database in the time from January 2013 to January 2019, with the key terms in English rheumatoid arthritis, biomarkers, antibodies and diagnosis, as well as texts doctors that contain information on rheumatoid arthritis, biomarkers and diagnosis in English and Spanish. Results: the scientific articles indexed in high impact factor magazine and with the best levels of evidence according to the Scimago system were selected and articles that were not related to our review objective such as clinical manifestations and arthritis treatment were excluded. Rheumatoid. Conclusions: Biomarkers are important in clinical management in the different phases of Rheumatoid Arthritis because they have been shown to help predict disease progression, improve diagnosis and even determine prognosis.