Función del complejo mayor de histocompatibilidad y el linfocito b en el rechazo de órganos

Abstract

Receiving a transplant allows us to replace an affected organ, restore health and prolong life. HLA and B lymphocytes are the protagonists of graft rejection, because they express the CD30 gene that helps them better recognize the organism's own antigens and cause the death of the transplanted organ. Therefore, we must ensure that the HLA and B lymphocytes do not recognize the graft as something foreign. The stated objective was to analyze the function of the Major Histocompatibility Complex and the B lymphocyte to understand its mechanism of action in organ rejection through a bibliographic review of databases and scientific journals. Conclusion HLA and B lymphocytes perform antigen recognition, antibody production and various immune functions that lead to rejection. The 80% loss of a graft is due to the crossed technique or Crossmatch-CDC, one of the most used worldwide.