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Título : Use of propolis in cancer Research.
Autor : Campo Fernández, Mercedes
Fecha de publicación : 2015
Editorial : India
Citación : Campo Fernández, M. (2015) Use of propolis in cancer Research. British Journal of Medicine & Medical Research.
Resumen : Interest to develop new anticancer drugs and to design combination treatments with little or no secondary effects provides new scope for traditional phytochemicals in chemoprevention and therapy. Propolis is a known source of polyphenols, and flavonoids found in them have been widely studied as biochemical markers for botanical origin and in explaining their antioxidant capacity as a key factor in chemoprevention. Antimicrobial, anti-inflammatory and anticancer biological activities of propolis are known. Studies of cancer cells to measure the anticancer effect of propolis are designed with one carefully chosen component, and with extracts applied to cells in culture media. The antitumor effect of propolis and caffeic acid phenethyl ester (CAPE), bioactive compound of propolis extract, is seen to be associated with its ability to initiate apoptosis of cancer cells. Chrysin is a flavonoid of interest to identify signaling molecules related to cancer. As cancer cells develop multidrug resistance (MDR) during chemotherapy, this opens a new avenue of research on cellular mechanisms of propolis components in combined treatments designed to overcome MDR.
URI : http://repositorio.utmachala.edu.ec/handle/48000/6532
ISSN : 2231-0614
Otros identificadores : British Journal of Medicine & Medical Research.
Aparece en las colecciones: SCOPUS

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